What is the best doses for CBD?

How much CBD should I take?

In general, the acceptance and use of cannabidiol as a therapeutic, healing substance is in its infancy. Medical professionals and scientists are only now beginning to develop dosing schedules for medical marijuana, medicinal hemp and their extracts (including CBD).

Even with the current wave of states that legalize medical marijuana, many doctors are reluctant to prescribe cannabinoids such as CBD. This is for two reasons:

1 – Doctors cannot prescribe cannabinoids (recommend only) because there is no recommended daily allowance (RDA) or universal dose for all people.

2 – Most medical schools never treat CBD / cannabidiol therapy in their pharmacology courses (the drug curriculum revolves primarily around substances that can be patented).

As there is no recommended dose, the information on this page is only intended as an informational guide – a reference point – and should never be considered as medical advice.

When it comes to cannabinoids, there’s a universal truth to keep in mind:

Everybody is different

There are countless variables such as weight, diet, metabolism, genetics, environment, product consistency and more that make a universally prescribed dosage impossible.

Although we wished we could provide the public with a mathematical CBD dosing calculator, it’s not that simple – very rough estimates are about as good as it gets.

With these facts in mind, most people who are new to cannabidiol start their journey by starting with the minimum proposed CBD dose for each product and then gradually increasing the dose until they achieve the desired results.

CBD Oil Review (COR) has created an official COR Serving Standard through an extensive analysis of hundreds of CBD products.

The (COR) Serving Standard is 25 mg CBD, taken twice a day.

In addition, our analysis suggests that you need to increase the amount of CBD you take every 3-4 weeks by 25 mg until you get symptom relief (conversely, decrease by 25 mg if symptoms get worse).

In addition, you may find it useful to record your daily experiences in a notepad, so that you can accurately determine what works and feels best for you.

With that understanding in place, it’s now time to learn more about CBD oil and how to find the right dose of CBD oil for you.

How much CBD oil should I take?

Mayo Clinic proposes CBD dosages based on scientific research, publications, traditional use and expert opinion. Cannabinoid dosages and duration of treatment depend primarily on the disease (and countless other factors).

Dosage recommendations for different diseases:

  • Loss of appetite in cancer patients: 2.5 mg THC (oral), with or without 1 mg CBD for six weeks.
  • Chronic pain: 2.5-20 mg CBD [with or without THC] (oral).
  • Epilepsy: 200-300 mg CBD (oral) daily.
  • Movement problems due to Huntington’s disease: daily 10 mg CBD per kg body weight for six weeks (oral).
  • Sleep disorders: 40 mg-160 mg CBD (oral).
  • Multiple Sclerosis (MS) symptoms: extracts of cannabis plants that contain 2.5 to 120 milligrams of THC / CBD daily for 2-15 weeks. Patients usually use eight sprays within three hours, with a maximum of 48 sprays in a 24-hour period.
  • Schizophrenia: 40-1.280 mg oral CBD daily.
  • Glaucoma: a single sublingual CBD dose of 20-40 mg (> 40 mg can increase eye pressure).

Learn the types of CBD products

CBD hemp oil comes in endless forms, each with a different concentration of CBD and different phytocannabinoids.

Determining the use of CBD oil starts with choosing your route of administration – in other words, choosing the best way to take CBD oil for your needs and lifestyle.

Among which…


  • Liquid hemp oil, such as CBD tinctures or CBD drops
  • CBD concentrated in a thick paste (often referred to as Rick Simpson Oil or RSO)
  • Encapsulated CBD oil
  • Phytocannabinoid-rich sprays / spritzers (usually designed for use under the tongue)
  • Bottled water with nano-sized CBD particles
  • CBD infused chewing gum
  • On-the-go soluble powders containing CBD (often mixed with other adaptogenic herbs)
  • Cooking oils (such as coconut oil or olive oil) with added cannabinoids
  • CBD-infused foods (ie gummies, brownies, cookies, etc.; usually for persons sensitive to smoking / vape)


  • Crystalline isolates
  • Wax (similar to THC-containing marijuana concentrates called “shatter”)
  • CBD-rich eLiquids and / or vape cartridges (related to an e-cigarette)


  • Transdermal patches with CBD (similar to a nicotine patch)
  • Ointment-soaked ointments, balms, lotions, shampoos or soap (for local use)
  • Bath bombs infused with CBD


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Determine how to use CBD oil

Although many options such as chewing gum do not require instructions, we have compiled these tips about taking CBD oil:

Liquid CBD oil / tinctures / extracts : drops or tinctures must have a “suggested portion size” and the total number of milligrams of CBD stated on the package.

From there you can determine the amount of CBD that you want to take. Simply place the correct amount of drops under your tongue using the dropper and hold the CBD oil in place for at least 60 seconds.

The 60 second hold ensures absorption through the blood vessels under your tongue – bypassing efficient first-pass metabolism. After 60 seconds have passed, swallow the CBD oil.

CBD E-Liquid / Vape Cartridges: Vapen is excellent for people looking for an immediate response, as inhalation is the fastest way to deliver CBDs to your brain and body.

To use vape, simply exhale the air from your lungs and then inhale slowly through the mouthpiece for 3 seconds.

Then fill your lungs the rest of the way with extra breath and hold for a few seconds and exhale when you’re done.

Pre-filled, inexpensive sheep pens and cartridges are available, as well as more expensive evaporators that you can refill with CBD infused e-liquid.

CBD Eetwaren: With edibles the only required steps are open, eat and enjoy! This consumption method will result in more long-lasting effects that also take longer to kick in than some of the other options.

Edible substances are great for people looking for long-lasting effects, or for those who want to be subtle about their use of CBDs.

CBD isolates / concentrates: anyone familiar with smoking hash or other cannabis concentrates such as wax and BHO is no stranger to this delivery method.

Simply sprinkle some in an evaporator or water pipe, ignite, inhale and enjoy! We find this option useful for people who want to increase their regular consumption of CBD-rich cannabis flowers or other smokable herbs.

For a quick reference, see the intake methods below for the advantages and disadvantages of each delivery method, so that you can decide for yourself the best way to take CBD oil:


Type of use method Operation Use before starting Duration of the effects Recommended if you….
Ingestion (eg Edible substances; capsules; oil drops; drinking powders) Useful; Dosage control; Discreet; It is not harmful to the lungs Takes effect slowly 30-60 minutes Edible substances / capsules: 4-6 hours; Tinctures / drops: 2-4 hours Consider discretion as a top priority and / or want more control over the dosage
Smoking products (e.g. Vapes; flour) Fast responding; Easy to use; social; familiar Non-discreet; Smoking / Vapen are illegal in many public institutions; Can feel hard on the lungs moment 45 minutes – 1 hour Trying to quit cigarettes or need fast-acting lighting
Topics (e.g. Lotions; balms; gels) Can be applied directly to the affected area; Bypasses liver metabolism; Long-term; Can be used in the daily hygiene routine Takes effect slowly Varies greatly due to factors such as hair growth and amount of fatty tissue Usually 5+ hours Experiencing local pain of the skin or joints or in body care in general.
Transdermal patches Longest lasting effects; bypasses liver metabolism; steady release of CBD in the bloodstream It can take hours to feel effects Varies depending on the amount of fatty tissue and hair on the skin 1-2 days Have chronic pain or will continue for a long period where the other delivery methods are not available. Swallow (eg Edible substances; capsules; oil drops; drinking powders)

Choose a CBD brand with a dosage that you can trust

Finding out how much CBD oil you should take can feel like trying to navigate through a complicated maze.

The large volume of CBD brands on the market can cause confusion among consumers, and if you look better, it’s not hard to understand why.

Sellers not only use different sources (CBD-rich cannabis versus industrial hemp, different types, etc.), but they also implement different extraction techniques.

In addition to the confusion, many suppliers recommend excessive doses, while others suggest quantities that are a fraction of what experts would consider effective.

As with fermented foods such as kombucha, slight natural variations are normal and to be expected in a product such as CBD oil because it is made from living plants.

Weather, soil and water changes can all influence the biology of the source material.

Although we verify the analysis certificates (and take into account many other criteria during our review process), even the most reputable five-star companies have no way of checking for every variable in this organic process.

Although perhaps not as ideal as a CBD dose table, we at CBD Oil Review (COR) have created an official COR serving standard through a comprehensive analysis of hundreds of products.

The (COR) Serving Standard is 25 mg CBD, taken twice a day.

In addition, our analysis suggests that you need to increase the amount of CBD you take every 3-4 weeks by 25 mg until you get symptom relief (conversely, decrease by 25 mg if symptoms get worse).

Consider why your health would benefit from CBD

Cannabinoids such as CBD have a dizzying array of functions in the human body that affect everything from inflammation to anxiety and depression .

You do not necessarily have to have a serious illness to benefit from CBD; even healthy individuals can experience a remarkable increase in their quality of life through its use.

The following diseases / conditions whose symptoms can be relieved by CBD:

  • Pain (neuropathic, chronic etc.)
  • epilepsy
  • Multiple Sclerose (MS)
  • Amyotrophic lateral sclerosis (ALS)
  • Parkinson
  • Inflammation
  • Acne
  • dyskinesie
  • psoriasis
  • Broken bones
  • Mad cow disease
  • Depression
  • Bacterial infections
  • diabetes mellitus
  • Rheumatoid arthritis
  • Nausea
  • Worry
  • Schizophrenia
  • Substance Abuse / Withdrawal
  • Heart disease
  • High bloodpressure
  • migraine
  • Irritable bowel syndrome (IBS)
  • Alzheimer

Please note that this CBD benefit list is in no way complete; we are just starting to discover how cannabinoids can help.


Know that you cannot take an overdose on CBD

There is no established lethal dose of CBD and chronic use / high doses of up to 1500 mg per day (30x MORE than the COR-serving standard!) It has been repeatedly demonstrated that it is well tolerated by humans.

As with any natural product, it is important to speak to your doctor before you start using it. There are some minor risks associated with using CBD in high dose or for a long time, including:

  • Mild low blood pressure
  • Dry mouth
  • Dizziness
  • Anesthesia
  • Decreased activity of T and B cells
  • Decreased fertilization capacity
  • Decreased p-glycoprotein activity
  • Decreased activity of cytochrome P450 (CYP450) enzyme

Keep in mind that these side effects illustrate sausage case scenarios with CBD and are not necessarily typical.

There is an important exception to the “generally harmless” attitude about CBD and that is the negative effect cannabinoids can have on the functioning of the liver’s CYP450 enzyme.

Approximately 60% of all pharmaceutical drugs undergo metabolism by this enzyme, including:

  • steroids
  • HMG CoA-reductaseremmers
  • Calcium channel blockers
  • antihistamine
  • prokinetische
  • HIV antiviral
  • Immune modulators
  • benzodiazepines
  • antiarithmic
  • antibiotics
  • anesthetica
  • antipsychotics
  • antidepressants
  • Anti epileptics
  • beta blockers
  • PPI
  • NSAID’s
  • Angiotensin II Blockers
  • Oral hypoglycemic agents
  • sulfonylureumderivaten

Read about drug interactions before you begin CBD.

It is important to note that even something as benign as grapefruit juice can cause the same CYP450 enzyme-inhibiting effect as CBD.

The most important things you should do before taking CBD (or another herbal product) are investigating possible drug interactions and consulting your doctor to answer additional questions regarding interactions between CBD or overdose. You and your doctor will always know together!

Understand how your genetics affects CBD dosing

As if you don’t have enough factors to consider when determining your ideal CBD oil dosage, you should now consider how your own genetics can influence this amount.

Some individuals were found to have mutations on the CNR1 gene, which is responsible for the coding of the CB1 receptor (a type of receptor in cells in your body that interacts with cannabinoids).

Problems with the CNR1 gene can ultimately lead to a malfunctioning endocannabinoid system, which is an important variable in figuring out how to use CBD oil.

Here are some other factors at the cellular level that can affect how CBD is absorbed into your body:

Various substances can have a profound effect on CB1 receptors. Certain lifestyle choices can affect how your body metabolizes CBD.

What does this mean?

Well, for example, THC increases the activity of CB1 receptors [1], while ethanol (alcohol) increases its expression [2]. In theory, smoking cannabis and drinking alcohol can therefore increase the effects of CBD.

Morphine and epinephrine reduce the activity of the CB1 receptor [3], [4].

What does this mean?

It may mean that those currently using opiates, with the approval and guidance of their physician, may find CBD helpful in reducing opiate use.

Exercise and nicotine both increase levels of anandamide (although similar to THC – this is a cannabinoid that we naturally synthesize in our brains), a natural CB1 receptor activator [5].

What does this mean?

Being active and taking nicotine (while the latter is not recommended) can increase the effect of CBD.

DHA (an omega-3 fatty acid) increases CB1 receptors [6].

What does this mean?

Theoretically, those who eat a diet rich in fatty fish should naturally use less CBD oil.

Prolonged elevated glucocorticoids (such as cortisol) reduce CB1 receptor density [7].

What does this mean?

Those with a high level of chronic stress may need a higher dose of CBD oil to achieve the same effects as people who are not chronically stressed.

We are only beginning to understand genetics, and as such it is a good idea to take everything that has to do with this emerging science with a grain of salt. As with any natural substance, consult your doctor about any questions and / or concerns you may have regarding CBD and the use of CBD oil.

Reassuringly, CBD Oil is not physically addictive

People often ask us: “Can I become addicted to CBD oil?” This is a difficult question, and the answer ultimately depends on how you think.

Strictly based on chemistry, the answer is no. Cannabidiol is not physically addictive in the same way that substances such as heroin, cocaine, alcohol, opiates, benzodiazepines, and related substances can be.

Furthermore, CBD itself cannot cause withdrawal symptoms when the use is stopped.

(Interestingly, CBD is currently investigating the ability to minimize withdrawal symptoms from drugs with severe strike symptoms, such as opiates.)

However, people can become addicted to just about anything that is not chemically addictive: exercise, music, sex and food are good examples.

Those who use CBD daily to relieve the symptoms of chronic diseases and other serious conditions may notice that their unpleasant sensations return shortly after they have missed a dose.

This is no different than the headache that returns once the effects of ibuprofen have disappeared.

However, since CBD can change the levels of essential liver enzymes, it is crucial to do your research, talk to your doctor, and find the best way to take CBD oil for your specific situation. Information and education will be your allies in your search for healing.

Get the most for your money

If you have been using CBD products for some time without verifying the potential of their suppliers, it is highly likely that you have used a minimally effective formulation that does not provide as much CBD as you thought (or as much as you paid).

This is why CBD Oil Review exists, why we have created our rating system with five badges, and why we have engaged independent reviewers to verify that CBD companies are ethically responsible.

Consider a cannabis doctor to answer your difficult questions

Most doctors are not specialized in medicinal cannabis and CBD oil. This means that they may not be able to help you as well as you had hoped and may not be able to provide guidance when it comes to helping you decide how much CBD oil you should take.

It is also worth noting that many patients feel uncomfortable talking to their doctor about cannabis and CBD.

It is important that you take CBD in the normal dose. The use of the oil is a better option because it will mix easily with your body and show more positive effects.

CBD Products that are sold in (online) stores may legally contain no more than 0.2% THC.

All products on  MHBioShop.com  contain  no or hardly any THC .

You can therefore not get high and there is also  no risk  of an overdose.

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