What exactly is CBD?
CBD stands for C anna B i D iol, one of the more than 100 identified cannabinoids that occur in the hemp plant.
Cannabidiol (CBD) is one of nature’s true, all-natural wonders. CBD harmonizes with the body’s endocannabinoid system, which is known to balance other body systems by improving intercellular communication.
Cannabidiol is a natural cannabinoid (phytocannabinoid) found in almost all types of Cannabis Sativa L.
More than 113 phytocannabinoids have been found in the cannabis plant . Cannabidiol (CBD), tetrahydrocannabinol (THC) and cannabinol (CBN) are the best known cannabinoids.
CBD was isolated and identified by Roger Adams in 1940, but its effects have only been thoroughly researched in recent years. These studies and the growing number of testimonials show that CBD has medicinal properties.
The reality behind the medical hype of cannabidiol
The cannabis compound known as CBD is touted as a treatment for a variety of conditions. But the uncertain legal status of the substance blocks a serious investigation.
Cannabidiol (CBD) is an illegal drug with no redeeming value. And it is a natural dietary supplement or “nutraceutical” among countless evangelists in the health and wellness community.
While contradictory, all three are true from different perspectives and clinical researchers are frustrated.
Numerous studies have shown that CBD is a safe and non-habit-forming substance that does not produce the ‘high’ associated with tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis.
In 2018, the U.S. Food and Drug Administration (FDA) determined that Epidiolex – a purified CBD product developed by GW Pharmaceuticals in Histon, UK – effectively reduces the frequency of seizures in certain rare forms of pediatric epilepsy.
This endorsement has strengthened the cannabinoid research community, which has long recognized the medicinal potential of CBD, but faces skepticism and regulatory limitations on its way to the clinic.
But at the same time, the many manufacturers promoting CBD-laden oils, lotions and foods as a panacea for various health problems, often with minimal observance of local laws or medical evidence, put the medical advocates of CBD in an awkward position.
Stuck in the weeds
Research into CBD in the 1970s and 80s focused on the interplay with other cannabinoids, particularly THC.
“While THC can cause psychotic symptoms, impair cognition and make people anxious, CBD seems to do the opposite,” said Philip McGuire, a psychiatrist at King’s College London.
A number of other studies exploring the compound’s pharmaceutical properties followed, although scientists who did early clinical research on CBD had to face a tough battle.
Claims of the health benefits of cannabis are often exaggerated and have no supporting evidence.
At least the mechanism of CBD’s action on cannabinoid receptors is well known. CBD can bind to the cannabinoid receptor CB 1, the same receptor that THC looks for in the brain.
However, unlike THC, CBD limits the CB 1 signaling rather than activating it, and therefore does not cause the psychoactive effects of its cannabinoid cousin.
But CBD wears a lot of hats. In addition, CBD acts on receptors that mediate pain signaling and inflammation, as well as at least one receptor for the neurotransmitter serotonin, 5-HT 1A 7.
Further experiments in rats failed to capture an antidepressant effect, but her team found that CBD-mediated modulation of 5-HT 1A could alleviate neuropathic pain in the animals.
In addition to epilepsy, clinical data in support of the medicinal benefits of CBD are more limited, mainly due to the small-scale and inconsistent design of studies.
Is CBD a medicine?
The answer is simply, no. CBD falls (still) under the category of dietary supplement, as long as it has not yet been approved by the authorities as a medicine, despite its medicinal effect.
Despite its promise, the impact of CBD as a medicine has been mixed. It is important that it is relatively safe.
The most common side effects of a high dose of Epidiolex are digestive problems, rashes and drowsiness, as well as the risk of liver damage in patients taking certain other medicines.
But in many of the CBD studies conducted so far – particularly in the field of antipsychotics, which are known for their strong side effects – CBD has proven to be more tolerable than existing alternatives.
“The side effects were not significantly worse than placebo,” said McGuire about his 2018 study of CBD in people with schizophrenia.
This is important because people typically need large doses of the drug to experience a clinical benefit – in many studies, the doses used are as much as 1 gram or more.
This is because CBD is poorly absorbed by the body, with most of each dose being excreted before it can have an effect.
“If you take it orally, the bioavailability is in the range of 4–6%, which is terrible,” says Devinsky. ‘If you take it after a fat meal, you can increase it to 16-20%
For example, while 300 milligrams of CBD can reduce a person’s anxiety symptoms, the same person may not get relief from a dose of 100 milligrams or 900 milligrams.
To complicate matters further, this good place for CBD dosing can differ not only between symptoms, but also between patients.
This is one of the many reasons why researchers warn against self-medication with CBD products aimed at consumers.
Where is CBD available?
CBD is available in stores worldwide, but the legality of such sales varies widely.
In Canada, the sale of cannabis and its derivatives is legal, while the European Union allows the sale of CBD derived from hemp (strains with a low THC content), but not from marijuana (cannabis with a high THC content).
In the United States, the latest Farm Bill, issued in 2018, may legalize the production of CBD from hemp under certain conditions – although sales of CBD products generally seem to remain illegal.
Regardless of the legal situation at the federal level, commercializing CBD in the United States remains free for everyone – individual states make their own laws, and the FDA has taken only limited measures to enforce federal laws on CBD.
“They’ve sent a number of messages to companies that have filed medical claims, but that’s about it,” said Marcel Bonn-Miller, a psychologist at the University of Pennsylvania, Philadelphia, and global science director at Canopy Growth Corporation, a cannabis company in Smiths Falls, Canada.
Claims About CBD
Many such claims are beyond the boundaries of medical evidence, including those regarding CBD preparations that claim to prevent cancer or treat Alzheimer’s disease.
But even products that make more modest claims can be problematic.
In addition, many commercially available preparations are contaminated with intoxicating doses of THC, heavy metals and pesticides, as well as toxic solvents from the CBD extraction process.
In a case reported by the U.S. Centers for Disease Control and Prevention, up to 52 people in Utah became seriously ill or were hospitalized after using a CBD oil containing an intoxicating synthetic cannabinoid.
The possibility of such contamination is of interest to all potential users, especially those seeking relief from the effects of a health condition.
“It’s one thing if you have too much THC in gummy bears that you use with friends, but it’s completely different if it’s a child who gives you CBD for medical reasons,” says Bonn-Miller. “I don’t trust a CBD product until I do the tests.”
Between two worlds
The regulatory disconnect surrounding CBD creates a strange situation where the public can self-medicate using a potentially questionable product, as scientists struggle to conduct high-quality clinical trials.
“The fact that CBD remains Schedule 1 in the United States is indisputable,” said Devinsky. That restrictive classification, he says, “damages research.”
It is already difficult to obtain sufficient amounts of pharmaceutical grade CBD to conduct a powerful clinical trial.
“It is extremely expensive,” says Leweke. “You need about one gram per day and the list price is about 60 euros per gram.”
This is because the process of extracting CBD from the cannabis plant is complex and arduous – and if the goal is to obtain CBD for use in humans, the substance must meet the high bar for clinical preparations, including only minimal amounts of THC or other contaminants are allowed.
Several companies have developed strategies for producing fully synthetic CBD, an approach that essentially addresses purity concerns.
But synthetic CBD is still under the Schedule 1 rating in the United States, creating additional economic and bureaucratic hurdles to clinical trials.
Even in Canada, where recreational cannabis has been legalized, Gobbi describes a complex application process and a wait of more than six months to obtain government approval to conduct a CBD study on humans or animals.
Unfortunately, if such studies are not carried out – or not done properly – consumers will be left to fend for themselves in a poorly guarded market.
In that scenario, the signal of true clinical benefit would almost certainly be drowned out by the sound of personal anecdotes and the placebo effect, which could jeopardize the future of a potentially valuable drug.
“People are notoriously bad when they think they see patterns,” says Devinsky. “If everyone is convinced they are right without data, I would call that religion – and CBD is currently religion for the average person.”
What is the difference between CBD oil and cannabis oil?
CBD oil, THC oil, cannabis oil, hemp oil … what is it all and what is the difference?
Are you so confused that you don’t know what to buy? You’re not the only one. Discover the differences between all these oils here!
Researching cannabis quickly shows that it is a complex plant. The herb is packed with molecules that all have different effects.
The plant produces a unique family of chemicals known as cannabinoids. More than 100 have been identified, and most that have been investigated show medicinal potential.
The two main cannabinoids found in most types of cannabis are THC – the psychotropic molecule that produces a high – and CBD, a non-psychotropic molecule that comes with a host of health benefits.
With the modern market of products with names like “CBD oil” and “cannabis oil”, what is the real difference between the two? Let’s start with some background information.
CBD IS FROM CANNABIS, BUT CANNABIS IS NOT CBD
Cannabis is almost always associated with the high produced by the plant’s THC-rich derivatives.
This cannabinoid binds to CB1 receptors in the central nervous system and causes a windfall of psychological and physiological results.
CBD, on the other hand, does not bind to this side and instead takes a more indirect route.
To take advantage of CBD – without the high caused by THC – the cannabinoid can be extracted from the cannabis plant and concentrated on its own.
However, marijuana strains produced for the recreational market usually do not contain enough CBD to make this process worthwhile, so industrial hemp is used instead.
This is a cannabis strain that contains negligible amounts of THC and a lot of CBD. This also makes hemp-derived CBD products legal throughout Europe, North America and many other parts of the world.
On the other hand, recreational cannabis plants can be used to create an extract rich in THC and CBD; however, the resulting product is considered cannabis oil, not CBD oil.
Let’s break it down further.
CBD oil and cannabis oil
What distinguishes CBD oil from cannabis oil is the THC content. CBD oil comes primarily from regulated industrial hemp and therefore contains only traces of THC (less than 0.3% in the United States).
These small amounts of the psychotropic molecule ensure that taking CBD oil, even in large amounts, will not get you high.
CBD products can now be found almost everywhere, including health food stores and some supermarkets.
This is because CBD is legal in many Western markets due to its good safety profile and lack of mind-altering properties.
This legality, sparking breakthroughs in scientific research, is why CBD has become such a widespread phenomenon.
WHY USE CBD OIL?
Studies have shown that CBD has anti-inflammatory, antioxidant, neuroprotective and anti-acidic effects, among other things.
The cannabinoid is thought to achieve these effects through multiple mechanisms. CBD interacts with the endocannabinoid system, a modulating system in the body that affects many physiological functions, including appetite, mood, metabolism, and immunity.
CBD oil is used by some in an effort to tame the symptoms of inflammatory conditions.
Research has shown that CBD has the potential to treat inflammatory bowel disease.
Athletes and active individuals also turn to CBD oil to reduce inflammation and muscle pain after exercise.
Anxiety and mood are also on the long list of conditions that CBD oil may help with.
The cannabinoid exerts broad therapeutic properties by acting on the central nervous system.
Since CBD oil is non-psychotropic, users can dose all day long without any mental obstruction.
Most high quality commercial CBD oils are full spectrum formulas .
This means that they contain other molecules of the hemp plant, such as terpenes, that have their own therapeutic properties.
Terpenes have been shown to work synergistically with CBD and may enhance some of the molecule’s medicinal properties. This synergistic mechanism is known as the entourage effect.
DIFFERENT TYPES OF CBD OIL
CBD oils on the market can be divided into two main categories: raw versus purified.
Products that are available in raw form look green-brown in color.
These extracts contain CBD and terpenes, but also contain chlorophyll, waxes and lipids, which reduces the concentration of CBD within each dose and results in an uneven liquid consistency.
The second category is purified “golden” CBD oil. This color difference is due to a process known as winterizing, which removes chlorophyll, wax and lipids, leaving a glistening end product.
WHAT IS CANNABIS OIL?
The difference between CBD oil and cannabis oil
Cannabis oil is made from cannabis strains with a high THC content.
This essentially means any cannabis strain with a THC content that can cause a mind-altering effect.
While cannabis oil may also have a high CBD content in some cases, it is not a CBD oil if it contains more THC than the legal threshold of 0.3%, or if it comes from recreational cannabis strains.
Cannabis oil is illegal in many countries, including most European countries.
The presence of THC makes cannabis oil an illegal substance in the eyes of the law and production and possesses its criminal offenses.
WHY USE CANNABIS OIL?
Despite what the law says, science paints a completely different picture. Sure, cannabis oil is psychotropic, but THC offers some very real medicinal properties.
This is why some regions, including many US states, legalize and decriminalize THC.
Some users prefer cannabis oil to treat symptoms precisely because of its psychotropic effect.
The high can be a powerful remedy for some people against bad mood, insomnia and stress.
THC also exerts anti-nausea effects and can increase appetite, making it extremely useful for people who experience side effects from medications such as chemotherapy.
The cannabinoid can reduce pain to a certain extent, but works more interesting when co-administered with CBD.
How do you make a cannabis tincture?
DIFFERENT TYPES OF CANNABIS OIL
Depending on where you live, cannabis oil is difficult to find. Many users make their own version at home with alcohol or oil-based extraction methods.
These formulas may contain a lot of THC and CBD, or a lot of THC. They can also retain some of the terpenes and other molecules, although not as effective as commercial methods such as CO2 extraction.
Quantification is a major problem in home extraction. Users rarely have a chance to analyze the exact amounts and content of their oil, while many high-quality CBD oils are subjected to laboratory tests.
Cannabis oil contains CBD, but also has a high THC content.
Cannabis oil is extracted from the resin of the female cannabis plant.
What are alternatives to CBD oil?
There are several ways to use CBD without any bad taste in the mouth and still experience the same effects.
Below are the best known and most used CBD alternatives:
Despite the known alternatives, despite the taste, many users prefer the drops and take the taste for granted. It is familiar and is immediately absorbed into the bloodstream for a quick effect.
Is CBD oil legal?
In short, yes. Since our Full Spectrum CBD oil contains less than 0.05% THC, it is completely legal in Europe and the USA.
Is CBD oil legal in the UK?
Hell yes. And because you have chosen a British company, you can be sure that our CBD oil complies with the law where you are.
Why is CBD oil legal?
Although CBD is cannabidiol and comes from the cannabis plant, it does not have any of the psychoactive properties of cannabis. This means you can enjoy all the health benefits of daily CBD oil without breaking the law or experiencing a high.
Will I pass a drug test?
In short, no. But if you want to know more, we have an entire section of facts devoted to this FAQ.
Will CBD oil make me high?
No, you don’t get high or feel ‘stoned’.
Full Spectrum CBD oil has been fully tested to ensure that it contains less than 0.05% THC, so it has no psychoactive effects.
However, CBD oil is believed to support your overall health and well-being, but it is not a miracle cure and not a drug that can cure all your pain and or conditions.
Need personal advice on CBD products?
Our team is ready for you via Live Chat, WhatsApp or simply by phone.
Medical and health claims prohibited
The Medicines Act within the EU does not allow medical or health claims to be made on food / nutritional supplements.
Since CBD is not officially a medicine, it is covered by the dietary supplements and claims on the effect of CBD are strictly prohibited.
This means that many things that we have wanted to discuss are not allowed.
We would also have liked to share experiences of CBD users worldwide, but unfortunately this is not allowed.
Undoubtedly, many details in our article have been removed due to the strict rules.
You are still free to find out for yourself, both online and offline, about the workings and experiences of cbd users, which we are not allowed to publish.
CBD Products that are sold in (online) stores may legally not contain more than 0.2% THC.
All products on MHBioShop.com contain little or no THC .
Therefore, you cannot get high and there is no risk of an overdose.