Can CBD oil help prevent or fight Coronavirus in you?

 

cbd in corona virus sars mers in anti-viral influenza

 

The headlines are frightening from Wuhan, China.

 

Guangzhou, a city with 15 million inhabitants, had just been locked up.

 

Can you imagine New York being locked up and quarantined?

 

Okay … so maybe this is not just another abnormal cold virus.

What about CBD?

We have seen reports that CBD has both antibacterial and antiviral effects.

This is definitely the time to do in-depth research into this  .

The reason for the push was a strange thing that we have noticed in the last 2 months.

 

My husband takes 300 mg CBD per day (research shows maximum dose for neurogenesis)  .

 

She avoided about 3-4 different colds and cases of flu that left the rest of the family a few months.

 

We were crammed into a hotel room during the winter break and she had none of it!

 

Occasionally a few cough showers or a small feeling like they were fighting something, but nothing close to what the other 3 family members had.

 

Was this just an event or anecdotal?

 

If you have read one of our reviews about CBD and anxiety or CBD and perimenopausal symptoms, you know that we are not tampering with anecdotes.

 

What does the research say for CBD and viral infections such as coronavirus or flu?

 

We cover the following topics:

  • How viruses such as coronavirus infect us and cause disease – A quick introduction
  • CBD’s effect on our immune response to coronavirus and others
  • Can CBD help with the corona virus?
  • CBD’s effect on the HIV aspect of coronavirus (ie the new Gilead medication)
  • CBD and the ACE2 receptor aspect of coronavirus
  • They support other antiviral supplements with NIH testing

 

First, a virus works like a small piece of genetic machinery. Not really alive because it needs a host cell to make more of it.

 

Once it gets access, it uses chemical keys on the outside of the dish to access our cells.

 

It then hijacks our cellular machines to make copies of it that are released into our bodies to continue the process.

 

You can see how this gets out of hand and engulfs our bodies.

 

That is a very simplified explanation, but it is sufficient  .

 

There are really three phases to watch from our point of view (the attacker):

  • Access to our body and our cell
  • Binding to the cell
  • Replication of more viruses
  • Release

 

Some interesting comments.

 

Ever wondered why viruses generally seem to swell in the winter?

 

The “shell” of the virus gets stronger with temperature drops:

At winter temperatures, the outer layer or coat of the virus hardens into a rubbery gel that can protect the virus as it passes from person to person, the researchers have found.

https://www.sciencedaily.com/releases/2008/03/080330203401.htm

 

This protective jacket disappears in the warmer summer seasons, making viral survival more difficult!

 

And yes … we are all in closed places in the winter, which does not help.

 

The speed of replication and our immune response to it are crucial for viral infections and their potential danger.

 

As researchers discovered in the deadly influenza pandemic of 1918, our overactive reaction was partly due to:

But in some cases, an infection can cause a reaction so destructive that it can be fatal. Scientists call this a cytokine storm because of the violent way in which immune cells respond to a virus.

https://www.washingtonpost.com/national/health-science/flus-lethality-is-attributed-to-immune-systems-overreacting-to-the-virus/2011/11/21/gIQA76GpWP_story.html

 

Cytokines are members of our immune system response .

 

 

 

Let’s go there now, because the overreaction of our immune system can be crucial to why a cold (also a type of corona virus) disappears while the new corona virus can kill.

The Response Of Our Immune System To Viruses Such As Coronavirus And Flu

Our immune system is far too complicated to enter here, but we can dance around the edges that are specific to viral infections.

 

As we saw above, what has killed many people with viral infections is not the virus itself, but the response of our own immune system.

 

There are first steps that the body will take against infections, such as an increase in body temperature or a decrease in tryptophan.

 

Increasing the temperature slows down viral replication and influences our immune response

 

We have discussed the tryptophan compound in our article on  tryptophan, inflammation and anxiety or depression,   because a drop also drops our serotonin there.

 

This is partly the reason why your mood may fall when you are sick.

 

The body tries to starve the protein that a virus or bacteria needs to make more of itself.

 

You also have the full power of the immune system’s response.

 

Part of this is innate or built into the system. The other part is adaptive, which the body learns from experiences with previous viral interactions.

 

That is the basis for vaccines.

 

There are a number of key players to watch without getting too complicated:

  • T cells – generals of the immune system
  • Macrophages – literally eat the viruses and need to be excreted (for example, when you blow your nose)
  • NK cells – natural killer cells

 

The basic approach of the immune system is to detect infected cells and to initiate cell death (called apoptosis).

 

Interestingly, this process is under the direction and control of the endocannabinoid system where CBD works!

 

We all have this system and it is responsible for balancing other important systems:

  • Endocrine system – hormones
  • Nervous system – neurotransmitters
  • Immune system – cytokines, macrophages, T cells

 

In the middle of the wheelhouse of viral reaction.

 

There is much evidence from in vivo and in vitro models showing that cannabinoids and their receptors influence the immune system, viral pathogenesis and viral replication.

https://www.ncbi.nlm.nih.gov/pubmed/26059175

 

Homeostasis is the key there with immune response.

 

That is just a nice word for balance.

 

We want an increased response to bending early in the process, while preventing so much additional damage and response that we are killed with the virus.

 

Viral replication rates are crucial here.

 

Some viruses such as the H5N1 virus have very high replication rates and our bodies panic.

 

Scorched earth.

 

Let us look directly at CBD with an addendum about THC (very different effects).

What Does CBD Do For The Immune Response

CBD has shown powerful effects to calm the immune response, but is that the wrong direction with viral infections?

 

Here’s the fascinating piece … CBD’s effects seem to change depending on the status of the system.

 

Most research looks at situations where the immune response is too high:

 

What about the opposite … situations in which the immune system has to start up but does not get out of hand?

 

After spending a few 1,000 hours in NIH research and writing a few 100,000 words on the subject, an interesting facet of CBD appears.

 

The effect is not in one direction.

 

Take cancer for example:

  • Healthy cell with low inflammation – CBD has no influence on inflammation levels
  • Healthy cell with high inflammation – CBD reduces inflammation
  • Cancer Cells – CBD INCREASES Inflammation

 

Read it carefully again, because it is downright revolutionary.

 

Most fabrics will push in one direction indefinitely.

 

Benzos (for GABA – see  CBD versus Benzos  ) or SSRIs for serotonin (see  CBD versus SSRIs  ) are perfect examples.

 

With a higher dose, they continue to raise levels … to a point where it can be dangerous.

 

Therefore, CBD does not cause sedation / overdose with GABA or serotonin syndrome with serotonin.

 

CBD acts as a contraint on various systems under endocannabinoid system regulation.

 

On both the low and the high side.

 

THC is anders.

 

THC pushes the CB1 receptor (our primary endocannabinoid receptor) in one direction.

 

Regarding viral infection, the study is not positive for THC, which is immunosuppressive, regardless of system needs:

For HSV-2, HIV-1, KSHV, influenza and VSV viral replication, or surrogate measures of infection, were found to be significantly increased when treated with cannabinoids.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903762/

 

This is not good and THC must be avoided during viral infection.

 

They tested THC in those situations that until recently were the dominant “cannabinoid”.

 

What about CBD and immune response to viruses?

 

In general, CBD calms the immune response during periods of inflammation.

 

Keep in mind that inflammation is only a code for an increased immune response that we want at the start of viral infections.

 

This is why we see its effects on the “damage” side of infection:

Together, our findings emphasize the anti-inflammatory effects of CBD in this viral MS model.

https://www.sciencedirect.com/science/article/pii/S0969996113001939

 

There are many studies from sepsis to stroke where CBD can calm the immune response to damage and improve function.

 

An example that is relevant here is a study of lung function after exposure to infection in mice:

The results show that CBD total lung resistance and elasticity, leukocyte migration in the lungs, myeloperoxidase activity in the lung tissue, protein concentration and production of pro-inflammatory cytokines (TNF and IL-6) and chemokines (MCP-1 and MIP-) reduced. 2) in the supernatant of the bronchoalveolar lavage.

https://www.ncbi.nlm.nih.gov/pubmed/25356537

 

If you looked at the Chinese doctor who had coronavirus describe how it felt, there was talk of tightening of the chest, lack of oxygen (he used oxygen breathing equipment), etc.

 

This is the immune system that fills the lungs with immune agents to a point where it can kill us before the virus does  .

 

It is auto-immune with a bang!

 

Let us investigate CBD directly with various viruses to ensure that it does not suppress our immune response when we really need it.

Can Help CBD With Viruses Such As Coronavirus And Flu

Perhaps the real benefit of CBD is the high-quality immune response we have seen with MS:

In addition, CBD administration at the time of viral infection has long-lasting effects, improving motor deficits in the chronic phase of the disease in combination with reduced microglial activation and pro-inflammatory cytokine production. 

https://www.ncbi.nlm.nih.gov/pubmed/23851307

 

That said, there are other important points of effect.

 

Do you remember how the immune system uses cell death to get rid of infected cells? It is called apoptosis.

 

CBD has a direct effect there (as with cancer cells):

Although CBD induced dose-dependent apoptosis in both cell types, at 0.25 to 1.0 µM, CBD induced significantly more cell death in virus-infected HMVECs than in post-infected HMVECs.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527984/

 

This is important. When they added CBD, there was an increase in cell death for virally infected cells (but not for healthy cells).

 

This “selective” effect is crucial when the immune system is on a warpath.

 

As they say:

These dose-response data indicate that endothelial cells infected with KSHV are more susceptible to CBD-induced apoptosis than spuriously infected endothelium and suggest that CBD may preferentially kill Kaposi’s sarcoma tumor cells over normal endothelium at specific concentrations.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527984/

 

Again, they used a virus to cause cell damage.

 

What about viral replication?

 

The only research we could find was for viral hepatitis:

CBD inhibited HCV replication by 86.4% at a single 10 μM concentration with EC50 of 3.133 μM in a dose response assay.

https://www.ncbi.nlm.nih.gov/pubmed/28250664/

 

What about interferon, one of the drugs that show some promise against coronavirus.

 

We know well from decades of research into HIV. Interestingly, HIV drugs show some potential against the corona virus.

 

Why is interferon important?

Virally infected cells produce and release small proteins, called interferons, that play a role in immune protection against viruses. Interferons prevent virus replication by directly disrupting their ability to replicate within an infected cell.

https://www.immunology.org/public-information/bitesized-immunology/pathogens-and-disease/immune-responses-viruses

 

Chronic inflammation and autoimmune disease studies have shown that CBD can suppress interferon.

 

Do the “biphasic” double effects also apply here when interferon is needed (such as with a viral infection)?

 

Another study looked at HIV (another type of viral infection): 

THC (but not CBD!) Suppressed secretion of IFN-α by pDC from both healthy and HIV + donors, arguing that although THC can affect antiviral responses, it can also be protective of neuro-inflammation associated with long-term HIV -infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686045/

 

IFN stands for interferon and CBD had a very different effect with a viral infection (in this case HIV).

 

Again, THC is not suitable for viral infections such as coronavirus or flu that are fast, acute and explosive in the body.

 

CBD did not suppress the major immune responses (IFN).

 

Again, this is the endocannabinoid system that is responsible for straightening the ship over the immune system.

 

There is a time and place for interferon to nail.

 

We can’t say it better than the researchers here:

Thirdly, our previous study showed that CBD inhibited or improved IL-2 and IFN-γ production in response to optimal or suboptimal T cell activation, respectively, which demonstrates that cellular activation dictates the CBD response.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327652/

 

IL-2 is one of those cytokines used by the immune system to fight infection.

 

It’s the role:

IL-2 is part of the body’s natural response to microbial infections and distinguishes between foreign (“not-self”) and “self”.

https://en.wikipedia.org/wiki/Interleukin_2

 

Let’s tie those pieces together.

 

T cells are the generals of our immune system that basically scan for intruders (virus) and collect the troops.

 

If you read above, CBD will boost two of the powerful T cell weapons (interferon and IL2) WHEN THE T cell function CONNECTS.

 

When T cell activity is too strong, it will actually suppress that activity (which is the key to autoimmune and inflammatory states).

 

T cell levels in the lungs are important for the new coronaviruses:

Interestingly, the acute phase of SARS in humans is associated with a serious reduction in the number of T cells in the blood.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125530/

 

See why we do so much at CBD?

 

This is our immune system, a ridiculously complicated patchwork quilt that has been made for hundreds of millions of years as an artifact of an arms race against a sea of ​​enemies.

 

  • Autoimmune drugs suppress immune function
  • Antiviral drugs strengthen immune function

 

None of them will respond according to the needs of the system.

 

That is why side effects can be so nasty in both extreme cases.

 

Again, the effect of THC is in one direction:

Treatment of mice with A9-THC resulted in sustained inhibition of IL-2 production even 7 days after treatment with cannabinoids.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470840/

 

IL2 is literally part of the system that detects the presence of a virus … a friend of enemy.

 

Probably the best list we’ve seen of either CBD’s immune suppression (in inflammatory states) or immune enhancement (in states of infection) can be found here:

https://www.liebertpub.com/doi/10.1089/can.2018.0073

 

Towards the end is a graph with immune-enhancing studies.

 

It is an impressive review (we are jealous).

 

We reported how T cells decreased in the acute phase of SARS (a similar type of coronavirus).

 

This is a fascinating result that directly points to the fatality of these viruses.

 

Let’s go there now.

CBD And The HIV Aspect Of Coronavirus

HIV is a fascinating (albeit heartbreaking) type of virus because it is specifically targeted at the generals of our immune response … T cells!

 

Wolf in sheep’s clothes.

 

They disarm the cell designed to protect against them.

 

There is an interesting facet with the new breed of coronaviruses (SARS, MERS, Wuhan Coronavirus).

 

Research on the SARS virus showed a significant “suicide” (apoptosis from above) or decrease in T cells during the critical period of the disease.

The effector phase of an immune response is followed by a strong contraction of the number of antigen-specific T cells, with 90-95% of the virus-specific T cells undergoing apoptosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125530/

 

This is strange because T cells should increase without committing cellular suicide.

 

That reveals how HIV medicines can promise to work with the corona virus.

 

Researchers have even established the shared mechanism:

This study points to a similar mode of action for the two viral proteins, suggesting that an antiviral strategy targeting the viral induced membrane fusion step can be taken from HIV-1 to SARS-CoV.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC222911/

 

In short, they say that the new strains of cororavirus share a number of similar pathways as HIV.

 

Whether this is “developed” is beyond our paygrade, but the location of Wuhan and the level 4 laboratory in China is curious at best.

 

In the meantime, the link between HIV proteins and the new corona virus is equally present:

We found 4 inserts in the spike glycoprotein (S) that are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all 4 inserts have identity or similarity to those in the HIV1 gp120 or HIV-1 Gag.

https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1.full.pdf

 

Those drugs revolve around blocking an enzyme called protease that viruses must replicate.

 

Seeds and roots are rich in those naturally (as a natural defense).

 

Chickpeas, soybeans, seeds, etc.

 

The HIV drug that China is currently investigating is Remdesiver, an antiviral drug developed by Gilead for Ebola and other viruses.

 

The mechanism is to act as adenosine, which confuses the virus replication process.

 

Are there other ways to stimulate this system naturally, but without the side effects?

CBD increases adenosine levels in the brain by reducing the re-uptake of adenosine. Increased adenosine is associated with neuroprotection and reduced inflammation after brain trauma.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938896/

 

Another study pointed to this pathway for CBD’s anti-inflammatory effects:

These studies demonstrate that CBD has the ability to improve adenosine signaling by inhibiting uptake and provides a non-cannabinoid receptor mechanism that can reduce CBD inflammation. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472541/

 

Again, adenosine interferes with the replication ability of the virus!

Coronavirus And The ACE2 Receptor Connection

There is an interesting piece of information from research into coronavirus.

 

Let’s take a short walk.

 

We have a system that controls the tightening and loosening of our cardiovascular system.

 

The tightening agent is called angiotensin  . It comes in two flavors and one has been made popular with blood pressure medications.

 

  • ACE2-remmers (angiotensineconversie- enzymblokkers )
  • ARB’s (Angiotensin Receptor Blockers)

 

The virulence or ability of the COVID19 coronavirus to cause death appears to be related to the number of angiotensin receptors and this varies by person and by race or origin.

 

Asians have some of the highest numbers of receptors.

 

There is an interesting graph here:

coronavirus- in ace2-receptorniveaus by flush

 

 

Why would this matter?

 

These receptors mainly occur in the heart and lungs (after all, they are cardiovascular in nature).

 

The lungs are naturally exposed to the coronavirus (and any external pathogen) and a unique ability of this specific virus is that it can more easily attach to the angiotensin receptors.

 

This then leads to the result of viral pneumonia causing the coronavirus to change from a cold to a deadly disease.

 

It would be interesting to see if ARBs (which block the receptors) have a protective effect on the corona virus, but that is for the researchers to find out.

 

In short, the virus has an easy way to (ACE2 receptors) and the immune system floods this area with cytokines.

 

This fills the lungs with the equivalent of snot or mucus (in fact our immune agents write large) and we literally drown in our own immune response.

 

One of the side effects of CBD is lower blood pressure, but we have no specific research on CBD and angiotensin receptors.

 

What we do find in research is how CBD calms the hyperactivation of the immune response in the lungs.

 

We saw the effects on mice that got a lung infection:

The results show that CBD total lung resistance and elasticity, leukocyte migration in the lungs, myeloperoxidase activity in the lung tissue, protein concentration and production of pro-inflammatory cytokines (TNF and IL-6) and chemokines (MCP-1 and MIP-) reduced. 2) in the supernatant of the bronchoalveolar lavage.

https://www.ncbi.nlm.nih.gov/pubmed/25356537

 

That’s a mouthful, but in fact CBD calmed the inflammatory immune response and improved lung function.

 

The leukocyte part is important  .

 

That is the immune response of white blood cells, which signals a cascade of other responders to walk on and causes inflammation that makes the cells of the lungs “leak.”

 

ACE2 receptors can act as easy access for the corona virus to cause damage and cause a storm in our lungs.

 

The effect of CBD seems to be a calmening of that storm.

 

Remember … it is generally not the virus that kills us, but the scorched response of our immune system.

 

View  CBD and inflammation  or  CBD and neuro-  inflammation    (both with a tendency toward anxiety testing) for deeper dives in these paths.

 

CBD is really powerful on that last piece that results from the hyperactivation of our immune system.

 

Always consult a doctor or naturopath with a supplement!

The information provided here is not intended to treat a disease or to replace   professional medical advice, diagnosis or treatment by a qualified health care professional.

 

0

Your Cart